"Expelliarmus is a useful spell, Harry, but the Death Eaters believe it's your signature move and I urge you not to let it become so!"
Remus Lupin to Harry Potter after the Battle of the Seven Potters[src]

A signature spell (or signature move) is the spell most commonly cast by a witch or wizard, especially when used in the context of duelling. Even though the spell may be the one the caster is best at, its predictability can make its user vulnerable.

According to Remus Lupin in 1997, Lord Voldemort's Death Eaters knew Harry Potter's signature spell was the Disarming Charm, and he urged Harry not to allow that to be the case. Despite this, Harry continued to make good use of the charm, and ultimately used it to defeat Voldemort.

The Killing Curse was known throughout most of the wizarding world to be Voldemort's signature spell, due to his frequent and indiscriminate usage of it; he certainly massacred enough to create an army of Inferi. He also invented the Morsmordre curse for his subordinates, to which it became somewhat of a signature as they usually cast it over locations where they commit murder.

Sectumsempra was invented by Severus Snape, and was thought to be his signature move, as Lupin noted after the Battle of the Seven Potters.

Death Eater Antonin Dolohov's repeated use of Antonin Dolohov's curse may also have made this a signature spell of his.

Ginevra Weasley was well-known for her ability to cast a particularly potent Bat-Bogey Hex, which could be considered her signature spell as she used it several times on people who annoyed her and was referred as "an accomplished caster" of the spell.

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