Lestrange is the surname of a pure-blood family. Lestrange could refer to:
- The Lestrange family
- Lestrange, a classmate of Tom Marvolo Riddle
- Bellatrix Lestrange née Black, a Death Eater and wife of Rodolphus Lestrange
- Rodolphus Lestrange, a Death Eater and husband of Bellatrix Lestrange née Black
- Rabastan Lestrange, a Death Eater and brother of Rodolphus Lestrange