Harry Potter and the Half-Blood Prince could refer to:
- Harry Potter and the Half-Blood Prince, the sixth book in the Harry Potter book series
- Harry Potter and the Half-Blood Prince (character index)
- Harry Potter and the Half-Blood Prince (film), the sixth film in the Harry Potter film series
- Harry Potter and the Half-Blood Prince (soundtrack), the soundtrack used in the film
- Harry Potter and the Half-Blood Prince (video game), the sixth video game in the Harry Potter video game series
- Harry Potter and the Half-Blood Prince (video game soundtrack), the soundtrack used in the video games
- The Half-Blood Prince, Severus Snape